3D-Bioprinting a Useful Tool for Study of Cancer Mechanisms

Published by , November 6, 2018 2:08 pm

(PhysicsWorld) Three-dimensional bioprinting has emerged as a useful tool for the study of cancer mechanisms, because it can mimic the in vivo microenvironment of tumour cells by the precise control of cells and biomaterials. Now, a team of researchers from Tsinghua University, Chinese Academy of Medical Sciences and Drexel University has implemented a 3D printed cervical tumour model to study the EMT process (Biofabrication 10 044102). Their findings provide a better understanding of the regulation mechanism of EMT, for use in future therapeutic programmes. NOTE: The epithelial–mesenchymal transition (EMT) is a process by which polarized epithelial cells undergo multiple biochemical changes
The researchers used HeLa cells (the oldest human cell line, derived from cervical cancer cells) to fabricate a cervical tumour model with a cuboid structure, with interconnected channels to facilitate sufficient transfer of nutrients, oxygen and metabolic waste. After printing, the cells proliferated and grew, confirming that the construct represents an advanced cancer model.
NOTE: For those interested in learning more about 3D Printing in Medicine, click here for details on The Future of 3D Printing in Medicine and Dentistry event in Boston 1/29-31. The 38% early bird special ends soon on November 8.

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